Gene OntologyWhat is Gene Ontology?The Gene Ontology (GO) initiative is an effort to provide consistent descriptions of gene products in a variety of databases. To achieve this goal, the GO project has developed three vocabularies, or ontologies, that describe gene products in terms of their molecular functions, cellular components, and biological processes. These vocabularies are structured to provide multiple tiers to allow for queries at different scales [1].
Identifying FANCL GO TermsGO terms for FANCL were found utilizing AmiGO 2, an online browsing tool that is part of the Gene Ontology Consortium website that searches for GO terms based on gene name [2]. To verify results and attain the ancestral term trees associated with each term, QuickGO, the EMBL-EBI GO term identifying browsing tool, was used [3].
Molecular Functions
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References
[1] The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat Genet. May 2000;25(1):25-9.
[2] Carbon S, Ireland A, Mungall CJ, Shu S, Marshall B, Lewis S, AmiGO Hub, Web Presence Working Group. AmiGO: online access to ontology and annotation data. Bioinformatics. Jan 2009;25(2):288-9.
[3] Binns D, Dimmer E, Huntley R, Barrell D, O’Donovan C, Apweiler R. QuickGO: a web-based tool for Gene Ontology searching. Bioinformatics. 2009;25(22):3045-3046. doi:10.1093/bioinformatics/btp536.
[2] Carbon S, Ireland A, Mungall CJ, Shu S, Marshall B, Lewis S, AmiGO Hub, Web Presence Working Group. AmiGO: online access to ontology and annotation data. Bioinformatics. Jan 2009;25(2):288-9.
[3] Binns D, Dimmer E, Huntley R, Barrell D, O’Donovan C, Apweiler R. QuickGO: a web-based tool for Gene Ontology searching. Bioinformatics. 2009;25(22):3045-3046. doi:10.1093/bioinformatics/btp536.
Image Resources
Figure 1: Gene Ontology Consortium logo
Figure 2: AmiGO logo
Figure 3: Ubiquitin-protein transferase activity parent terms tree
Figure 4: Fanconi Anemia nuclear complex parent terms tree
Figure 5: Protein ubiquitination parent terms tree
Figure 6: DNA repair parent terms tree
Figure 2: AmiGO logo
Figure 3: Ubiquitin-protein transferase activity parent terms tree
Figure 4: Fanconi Anemia nuclear complex parent terms tree
Figure 5: Protein ubiquitination parent terms tree
Figure 6: DNA repair parent terms tree